According to the new research published in the Journal of Biological Chemistry, the research would assist to evolve new therapies for managing metabolic diseases. In this study, scientists have found that low levels of a flowing hormone called ‘adropin’ predicts increased weight gain and metabolic dysregulation through-out the consumption of a high sugar diet in a nonhuman placental-mammal replica.
Obesity is an increasing health issue, which may include various severe risk factors like cardiovascular disease and type 2 diabetes.
Researchers face an urgent need to better understand how the body burns fat because the number of people who are either overweight or obese, now, outnumbers those by a ratio of two to one with a healthy body weight.
Andrew Butler, a professor of pharmacology and physiology had come across this several years ago, with the peptide hormone adropin. This research by Butler’s lab puts forward that adropin controls whether the body burns glucose or fat. They also came to know, that young men with high adropin levels had lower body mass index (BMI) levels. Furthermore, some studies showed that low adropin is related with biomarkers of insulin resistance.
Research of this new study was conducted at California National Primate Research Center by Butler and his team in order to traverse adropin’s role in metabolism. In this, they inspected the plasma of 59 adult male rhesus macaques provided food with a high sugar diet. The consumption of this fructose diet produced a 10 per cent gain in body weight and increases of fasting levels of insulin, indicating insulin resistance, which lessen glucose use and raised fasting triglycerides, which in humans increases the risk of cardiovascular disease.
They examined that an animal with low plasma adropin, developed a more serious metabolic symptoms and type 2 diabetes was observed. These animals also showed more noticeable dysregulation of glucose and lipid metabolism.
Butler said, “Monkeys with low adropin, may therefore not be oxidising glucose as well, explaining their higher fat content as the glucose is converted to lipids instead of being used as a metabolic fuel.”
In inclusion he said, “Last year we reported that adropin appeared to be an output of the biological clock using mouse models and cultured human cells. What we show in this paper is that expression of the ENHO gene is higher in daytime and lower at night in most primate tissues.”
This contemporary research suggests that adropin may relate with the biological clock to rhythms in the way the body utilise sugar and fats as metabolic fuel.
Butler said that at night time, the body relies on energy reserves stored as lipids in fat cells and during the day it relies more on the carbohydrates coming in from the diet.